How often should a Vanco trough be drawn?

-Vancomycin trough levels should ideally be drawn immediately before administration of the fourth dose (within 30 minutes of the dose is acceptable), assuming the dose is given at its regular dosing interval (e.g. the fourth dose of a vancomycin 1g q12h regimen is administered 12 hours after the prior dose).Click to see full answer. Regarding this, when should trough levels be drawn?A trough level is drawn immediately before the next dose of the drug is administered. A peak level is drawn 1 to several hours after the drug is administered (depending on the drug).Secondly, what happens if Vanco trough is high? Recent guidelines have recommended vancomycin trough levels of 15–20 mg/L for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA). However, high trough levels may increase risk of nephrotoxicity and mortality, and high vancomycin trough levels have not been well studied. Furthermore, when should vancomycin levels be taken? Specimens for vancomycin trough concentrations should be obtained just prior to (that is, 30 minutes before) the fourth dose (including the loading dose, if given) or at steady state. At five half-lives, about 97% of steady-state serum concentrations will be reached.What causes high vancomycin trough levels?Several risk factors have been identified for VIN, which high trough vancomycin level (especially >20 mg/L) or doses (>4 g/day), concomitant use of nephrotoxic agents, prolonged therapy (more than 7 days), and admission to an intensive care unit (especially prolonged stay) are the most common ones (1-4, 14).